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. 2023 Oct 7;44(44):4622–4633. doi: 10.1093/eurheartj/ehad637

Figure 4.

Figure 4

Cine end-diastolic cardiac magnetic resonance images of a patient with obstructive hypertrophic cardiomyopathy: effects of mavacamten. Baseline before treatment (A and C) and after 30 weeks of mavacamten (B and D). Mid short axis (A and B). Four-chamber long axis (C and D). Compared with baseline, at Week 30, left ventricular mass and maximal wall thickness were reduced from 149 g/m2 and 26 mm to 117 g/m2 and 20 mm, respectively; maximal left atrial size fell from 77 to 59 mL/m2. Left atrial total emptying fraction increased from 27% to 50%. Data are from the EXPLORER-HCM trial.36,48 Images courtesy of Dr Raymond Kwong, Brigham and Women’s Hospital.