Table 2.
Changes in cytokines from pre- to post-chemotherapy or time equivalent in controls.
| Variables |
|
Patients with Breast Cancer (n = 78) |
|
Age-matched Controls (n = 78) |
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|---|---|---|---|---|---|---|---|---|---|---|
| Pre-chemo | Post-chemo | Change | p- valuea |
Pre-chemo time equivalent |
Post-chemo time equivalent |
Change | p- valuea |
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| N Analyzed |
Mean (SD) | Mean (SD) | Mean (SD) | N Analyzed |
Mean (SD) | Mean (SD) | Mean (SD) | |||
| Cytokine (pg/mL) | ||||||||||
| IL-1β (log) | 77 | −0.78 (1.51) | −1.03 (1.40) | −0.25 (0.71) | 0.003 | 77 | −0.13 (1.87) | −0.09 (1.95) | 0.04 (0.50) | 0.450 |
| IL-6 (log) | 77 | 1.42 (2.28) | 1.97 (1.96) | 0.55 (2.21) | 0.032 | 77 | 1.95 (2.67) | 2.24 (2.55) | 0.29 (1.47) | 0.089 |
| IL-8 (log) | 77 | 2.39 (0.84) | 2.36 (0.80) | −0.03 (0.81) | 0.811 | 77 | 2.62 (0.84) | 2.68 (0.80) | 0.06 (0.47) | 0.469 |
| MCP-1 | 76 | 895.75 (353.39) | 1099.45 (489.76) | 203.70 (357.42) | <0.001 | 74 | 906.35 (377.87) | 991.29 (445.24) | 84.94 (184.67) | <0.001 |
| sTNFRI | 76 | 178.97 (94.96) | 214.35 (104.29) | 35.38 (79.09) | <0.001 | 77 | 197.56 (74.74) | 195.61 (69.92) | −1.94 (81.75) | 0.836 |
| sTNFRII | 75 | 1093.81 (499.06) | 1329.01 (515.68) | 235.20 (412.93) | <0.001 | 76 | 1123.94 (355.53) | 1134.65 (361.50) | 10.71 (421.74) | 0.825 |
When baseline or change score values of cytokines/receptors were greater than three standard deviations from the mean, we dropped the data from that participant for that particular measure. This effected between 1 and 3 of 78 data points per marker.
t-tests are performed to examine the difference in cytokines from pre- to post-chemotherapy, or time-equivalent for controls.
a
p-values tests the null hypothesis of no pre- to post- difference via paired t-test. IL= interleukin, MCP-1 = monocyte chemoattractant protein-1, sTNFR= soluble tumor necrosis factor receptor