Table 3.
IPD incidence rates ratio in children aged 0 to 9 years with HbSS or HbSC compared with the reference population
| Outcome | Population | IPD incidence rate ratio, SCD vs reference population, (95% CI), P value |
|||
|---|---|---|---|---|---|
| Pre-PCV period, 1994-1999 |
PCV7 period, 2000-2009 |
PCV13 period, 2010-2018 |
Overall period, 1994-2018 |
||
| All IPD | HbSS | 22.7 (16.3-30.8), <.001 | 28.7 (19.8-40.4), <.001 | 32.9 (18.8-54.1), <.001 | 24.4 (19.6-30.1), <.001 |
| HbSC | 14.2 (7.6-26.4), <.001 | 6.4 (2.1-19.9), .001 | 20.6 (7.7-55.4), <.001 | 11.4 (7.0-18.3), <.001 | |
| HbSS/SC | 20.2 (15.1-26.6), <.001 | 22.1 (15.5-30.7), <.001 | 29.2 (17.8-45.7), <.001 | 20.5 (16.9-25.0), <.001 | |
| Meningitis | HbSS | 73.0 (22.0-191.0), <.001 | 96.7 (36.9-219.6), <.001 | 28.0 (1.3-154.1), .038 | 69.0 (35.1-125.6), <.001 |
| Death | HbSS | 250.1 (88.4-639.4), <.001 | 49.8 (2.3-291.8), .022 | 95.1 (4.0-686.7), .013 | 138.9 (59.7-294.2), <.001 |