Table 4.

Non-PCV13 IPD in children with SCD and IPD, serotype coverage by PPSV23, PCV15, PCV20, and PCV21/V116

Data	IPD	PPSV23 serotype		PPSV23∗ serotype		PCV15 serotype		PCV20 serotype		PCV21 serotype		Total non-PCV13 serotypes
		n	%	n	%	n	%	n	%	n	%	n	%
Present†	All	11	30	23	62	6	16	19	51	34	92	37	100
	Meningitis	2	50	4	100	0	0	3	75	4	100	4	100
	Death	1	50	2	100	0	0	2	100	2	100	2	100
	Meningitis/death	3	50	6	100	0	0	5	83	6	100	6	100
Pooled‡	All	7	14	23	50	2	4	18	39	37	80	46	100
	Meningitis	0	0	1	50	0	0	1	50	1	50	2	100
	Death	0	0	4	67	0	0	3	50	5	83	6	100
	Meningitis/death	0	0	5	71	0	0	4	57	6	86	7	100
Present†+ pooled‡	All	18	22	46	55	8	10	37	45	71	86	83	100
	Meningitis	2	33	5	83	0	0	4	67	5	83	6	100
	Death	1	13	6	75	0	0	5	63	7	88	8	100
	Meningitis/death	3	23	11	85	0	0	9	69	12	92	13	100

Serotype 15C assumed covered in PCV20³⁷; and serotype 6C and 15C covered in PCV21.³⁵

Each column is a different subgroup of the total. All non-PCV13 IPD, irrespective of period when these occurred.

^∗Vaccine-related serotype 15A³⁵ and 15C^35,36 assumed to be covered in PPSV23.

^†15BC in 9 cases (24%); 15A, 22F, or 23B in 4 (11%) cases each; 06C or 12F in 3 (8%) each; 33F or 35B in 2 (5%) each; 7C, 10A, 16F, 23A, or 38 in 1 (3%) case each.

^‡IPD serotype data in children with SCD, from previously published data.^{13,40,49,50,71,72,73,74,75,76,77,78}