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. 2023 Nov 2;26(6):540. doi: 10.3892/ol.2023.14127

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Copyright: © Chang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 9. — Effects of DHA treatment, CaMKK2 siRNA, CaMKK2-OE and NCLX siRNA on ATP synthase expression. (A) Western blotting and protein expression levels of (B) ATP1A1, (C) ATP5H, (D) CaMKK2 and (E) NCLX in HepG2 cells transfected with CaMKK2 siRNA, CaMKK2-OE and NCLX siRNA and treated with DHA. (F) Western blotting and protein expression levels of (G) ATP1A1, (H) ATP5H, (I) CaMKK2 and (J) NCLX in HuH-7 cells transfected with CaMKK2 siRNA, CaMKK2-OE and NCLX siRNA and treated with DHA. All data are presented as the mean ± standard deviation (n=3). Data were analyzed using one-way analysis of variance followed by Bonferroni post hoc test. **P<0.01, ***P<0.001. NCLX, mitochondrial sodium/calcium exchanger protein; DHA, dihydroartemisinin; CaMKK2, calcium/calmodulin-dependent protein kinase kinase 2; siRNA, small interfering RNA; OE, overexpression; ns, not significant; NC, negative control; ATP1A1, sodium/potassium-transporting ATPase subunit α-1; ATP5H, ATP synthase subunit d, mitochondrial.