Antimicrobial activity of compounds 1 and 2 (200 μg/8 mm disc), the broad spectrum antibacterial drugs gentamicin sulfate (100 μg/8 mm disc), ampicillin trihydrate (100 μg/8 mm disc) and the antifungal drug clotrimazole (100 μg/8 mm disc) against Staphylococcus aureus ATCC 6571 (SA), Bacillus subtilis ATCC 5256 (BS), Micrococcus luteus ATCC 27141 (ML), Escherichia coli ATCC 8726 (EC), Pseudomonas aeruginosa ATCC 27853 (PA), and the yeast-like pathogenic fungus Candida albicans MTCC 227 (CA).
| Compound | Diameter of growth inhibition zonea (mm) | |||||
|---|---|---|---|---|---|---|
| SA | BS | ML | EC | PA | CA | |
| 1 | 21 (4) | 18 (16) | 16 | 12 | — | 11 |
| 2 | 22 (8) | 24 (2) | 18 (16) | 11 | — | — |
| Gentamicin sulfate | 27 (1) | 26 (2) | 20 (2) | 22 (0.5) | 21 (0.5) | NT |
| Ampicillin trihydrate | 22 (2) | 23 (1) | 20 (2) | 16 (8) | 18 (8) | NT |
| Clotrimazole | NT | NT | NT | NT | NT | 21 (4) |
a
Figures shown in parentheses represent the MIC values (μg mL−1), NT: not tested, (−): inactive (inhibition zone < 10 mm.