Table 2. Demographic Characteristics, Baseline Characteristics, and Risk Factors for Children of Women With Epilepsy vs Women Without Epilepsy in Primary Analysis 1: Continuous Variablesa.
| Continuous variable | Children of women with epilepsy (n = 302) | Children of women without epilepsy (n = 84) | P valueb | ||||
|---|---|---|---|---|---|---|---|
| No. | Mean (95% CI) | Median (range) | No. | Mean (95% CI) | Median (range) | ||
| Birth weight, kg | 295 | 3.2 (3.2-3.3) | 3.2 (0.6-4.9) | 84 | 3.3 (3.1-3.4) | 3.3 (1.1-5.0) | .61 |
| Mother’s age at enrollment, y | 302 | 30.8 (30.3-31.4) | 31 (18-46) | 84 | 29.8 (28.7-30.9) | 31 (15-38) | .09 |
| Mother’s IQ | 302 | 98.3 (96.8-99.7) | 100 (58-124) | 84 | 104.6 (101.7-107.5) | 106 (72-131) | <.001 |
| Beck Depression Inventory–2c | |||||||
| Enrollment through 2-y visit | 301 | 6.3 (5.7-6.9) | 5.3 (0.0-36.8) | 84 | 5.1 (4.3-6.0) | 4.7 (0.0-24.0) | .09 |
| Pregnancy | 302 | 7.1 (6.5-7.7) | 5.7 (0.0-38.7) | 84 | 5.9 (5.0-6.8) | 5.0 (0.0-17.7) | .11 |
| After birth | 301 | 5.8 (5.2-6.5) | 4.5 (0.0-35.6) | 84 | 4.5 (3.6-5.5) | 3.7 (0.0-29.0) | .06 |
| Beck Anxiety Inventoryc | |||||||
| Enrollment through 2-y visit | 301 | 5.2 (4.7-5.7) | 3.8 (0.0-34.1) | 84 | 3.5 (2.7-4.4) | 2.7 (0.0-26.0) | <.001 |
| Pregnancy | 302 | 6.4 (5.8-7.1) | 4.8 (0.0-38.3) | 84 | 4.9 (3.9-5.9) | 3.4 (0.0-29.3) | .03 |
| After birth | 301 | 4.4 (3.9-5.0) | 3.0 (0.0-31.6) | 84 | 2.6 (1.8-3.5) | 1.5 (0.0-23.5) | <.001 |
| Perceived Stress Scale–14c | |||||||
| Enrollment through 2-y visit | 301 | 17.9 (17.1-18.6) | 17.6 (3.3-40.6) | 84 | 16.9 (15.8-18.0) | 17.2 (6.4-29.1) | .32 |
| Pregnancy | 302 | 18.0 (17.2-18.8) | 17.7 (2.7-40.0) | 84 | 16.3 (15.0-17.6) | 15.7 (3.3-30.5) | .09 |
| After birth | 301 | 17.8 (17.0-18.6) | 17.6 (2.0-41.0) | 84 | 17.2 (16.0-18.4) | 16.9 (6.2-33.0) | .54 |
| Pittsburgh Sleep Quality Indexd,e | |||||||
| Pregnancy and post partum | 237 | 5.7 (5.4-6.1) | 5.6 (0.1-13.7) | 64 | 5.3 (4.7-5.9) | 5.0 (1.0-12.3) | .17 |
| Pregnancy | 276 | 5.8 (5.4-6.1) | 5.3 (0.0-15.5) | 75 | 4.7 (4.1-5.3) | 4.3 (1.0-11.8) | .005 |
| Post partum | 240 | 5.7 (5.4-6.0) | 5.4 (0.0-13.6) | 64 | 5.6 (4.9-6.3) | 5.8 (0.3-12.5) | .89 |
Missing values not used in calculation of P values. Table only includes risk factors and covariates included in primary analysis models. Complete tables are eTables 4 and 5 in Supplement 1.
From the t test (birth weight, age, IQ, and Pittsburgh Sleep Quality Index scores) and Wilcoxon rank sum test (Beck Depression Inventory–2, Beck Anxiety Inventory, and Perceived Stress Scale–14 scores).
Mean of all assessments completed during time period. Pregnancy: enrollment through day of delivery; after birth: after delivery through 2-year visit.
Pittsburgh Sleep Quality Index scores not assessed for inclusion in imputation model due to extensive missing data.
Weighted monthly mean of Pittsburgh Sleep Quality Index assessments completed during time period. At most, 1 Pittsburgh Sleep Quality Index score per day was used in the calculation. Pregnancy: enrollment through the day before delivery; post partum: 6 weeks through 9 months after delivery; and pregnancy and post partum: assessments completed during either period (only women with scores in both periods included).