Fig. 3.

Details of p-BRCA mutations. (A) Among the p-BRCA mutations detected in gastric cancers of 65 patients, 39% show loss of heterozygosity of the mutant allele (LOH+). (B) The detected p-BRCA mutations are scattered throughout the entire exonic area without major hotspots. (C) The variant allelic fractions of p-BRCA mutations with loss of heterozygosity are significantly higher than those of p-BRCA mutations without LOH (p < .001). p-BRCA mutation, pathogenic or likely pathogenic BRCA1 or BRCA2 gene mutation.