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. 2023 Nov 19;13(11):e079063. doi: 10.1136/bmjopen-2023-079063

Table 4.

; Bivariable and multivariable Weibull regression analysis for predictors of RDS among low birthweight neonates in their first 7 days of life in Northwest Ethiopia Comprehensive Specialised Hospitals from 19 September 2021 to 1 January 2023 (n=405)

Variable Status CHR (95%CI) AHR (95%CI)
Event Censored
Sex
Male 95 123 0.78 (0.59 to 1.03) 0.82 (0.61 to 1.10)
Female 98 89 1 1
Mode of delivery
Instrumental assisted 6 10 0.50 (0.22 to 1.13) 0.48 (0.205 to 1.32)
CS 35 53 0.60 (0.42 to 0.87) 0.62 (0.41 to 0.93)**
SVD 152 149 1
Type of pregnancy
Multiple 60 41 1.50 (1.10 to 2.04) 1.43 (1.04 to 1.96)**
Single 133 171 1
Pre-eclampsia
Yes 52 51 1.17 (0.85 1.61) 1.14 (0.80 to 1.62)
No 141 161 1 1
PNA
Yes 28 28 1.24 (0.83 to 1.85) 1.26 (0.82 to 1.94)
No 165 184 1 1
NEC
Yes 10 7 1.44 (0.76 to 2.72) 1.40 (0.73 to 2.69)
No 183 205 1 1
IUGR
Yes 5 13 0.39 (0.14 to 1.03) 0.67 (0.24 to 186)
No 188 199 1 1
First-minute APGAR score
˂7 85 68 1.48 (1.11 to 1.97) 1.08 (0.77 to 1.51)
≥7 108 144 1 1
Fifth-minute APGAR score
˂7 32 14 1.94 (1.33 to 2.83) 1.86 (1.18 to 2.92)***
≥7 161 198 1 1
Gestational age in weeks
<37 156 123 2.09 (1.43 to 3.05) 1.56 (1.06 to 2.30)**
≥37 37 89 1 1
Birth weight
≤999 15 6 3.52 (2.11 to 5.86) 3.14 (1.81 to 5.40)***
1000–1499 60 24 2.43 (1.78 to 3.33) 2.06 (1.42 to 2.83)**
1500–2499 118 182 1 1

**=Statistically significant variables with p-value <0.01, & ***p<0.001.

1, reference; AHR, Adjusted Hazard Ratio; APGAR, Appearance, Pulse, Grimace, Activity, Respiration; CHR, Crude Hazard Ratio; CS, caesarean section; IUGR, intrauterine growth restriction; NEC, necrotising entero colitis; PNA, perinatal asphyxia; SVD, spontaneous vaginal delivery.