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. 2023 Oct 12;26(11):108180. doi: 10.1016/j.isci.2023.108180

Figure 4.

Figure 4

FIS assay of W57G/A234D nasal organoids

(A) Representative bright-field images of W57G/A234D nasal organoids stimulated with 10 μM of FSK with or without CFTR modulator treatment, as indicated.

(B) Quantification of FIS rates after the addition of 10 μM forskolin + 5 μM VX770 on 48 h pre-treated nasal organoids with indicated CFTR modulators.

(C) Correlation plot of AUC (X ax Colon and Y ax Nasal organoids, R2 = 097, p < 0.0001). Dashed blue line represents best-fit values. The two black dotted lines represent 95% confidence interval of the best-fit line. Ordinary one-way ANOVA: ∗< 0.05; ∗∗p < 0.002; ∗∗∗p < 0.0002; ∗∗∗∗p < 00001.