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. 2023 Nov 15;13(11):e075588. doi: 10.1136/bmjopen-2023-075588

Figure 1.

Figure 1

Stress Ulcer Prophylaxis Research Program. In preparation for this trial, with national and international collaborators, we developed this stress ulcer prophylaxis research programme. We published several reviews and meta-analyses on acid suppression. We contributed to an international period prevalence epidemiological study which assisted with some Re-Evaluating the Inhibition of Stress Erosions (REVISE) trial estimates. We completed two surveys about stress ulcer prophylaxis in Australia and Canada. We completed two pilot randomised trials in preparation for REVISE. The 214-patient, single-centre Australian Pantoprazole versus Placebo for Stress Ulcer Prophylaxis (POP-UP) Pilot trial achieved three objectives related to exploring overt signals of benefit or harm, ascertaining whether the study drug could be administered promptly after commencing mechanical ventilation, and estimating relevant outcome event rates. A second 91-patient, international REVISE Pilot Trial achieved three feasibility objectives related to rates of recruitment, informed consent and protocol adherence. Other international studies provided key evidence to help inform the design of the main REVISE Trial. PEPTIC, Proton Pump Inhibitors vs Histamine-2-Receptor Blockers for Ulcer Prophylaxis Treatment in the Intensive Care Unit; RCT, randomized clinical trial; SUPICU, Stress Ulcer Prevention in the ICU.