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. 2023 Aug 22;43(8):1724–1739. doi: 10.1007/s10875-023-01558-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Flowchart of the Covimmune 2 study. Blood samples and data were collected at three time points (month 0, month 6 and month 12) starting in July 2020. At month 0 (n = 555) and month 6 (n = 463), only B cell response was assessed. For month 12, both B cell and T cell responses were measured. At the end of month 12 (December 2021), 367 participants had a complete set of data for the three time points. According to history of vaccination and SARS-CoV-2 infection, participants were classified as vaccinated and naive to infection (n = 212, 47 excluded), vaccinated and previously infected (n = 68, 14 excluded), non-vaccinated and non-infected (n = 16) and non-vaccinated and infected (n = 10)