Table 3.

CT methods assessing hepatic fibrosis

Approach	Acronym	Description
Morphology-based score	CRL-R	Caudate-right-lobe ratio = caudate lobe diameter/right lobe diameter
	LIMV-FS	Liver imaging morphology and vein diameter fibrosis score = liver vein diameter/caudate-right-lobe ratio
	LIMA-FS	Liver imaging morphology and attenuation fibrosis score = caudate-right-lobe ratio × liver vein to cava attenuation
	LIMVA-FS	Liver imaging morphology, vein diameter and attenuation fibrosis score = liver vein diameter/caudate-right-lobe ratio × liver vein to cava attenuation
Contrast-enhanced biomarkers	NIC	Normalized iodine concentration = iodine concentration liver/ iodine concentration aorta The ICratio was defined as ICAP/ ICPVP, where ICAP and ICPVP denoted iodine concentrations during AP and PVP, respectively
	ECV	Hepatic extracellular volume—Hounsfield units (%) = △Hounsfield units liver × (100–1-hematocrit (%))/△Hounsfield units aorta △HUlive indicates the difference in HUs between the precontrast and equilibrium phase
Postprocessing methods	LSN	A semiautomated postprocessing software
	LSVR	A dedicated computed tomography software tool
	TA	A commercially available texture analysis research software platform
	DLS	The steps for deep learning system: Input CT images $\to$ Liver segmentation algorithm $\to$ Segmented liver images $\to$ Liver fibrosis staging algorithm $\to$ Output
Radiomics		The steps for radiomics: Importing CT images $\to$ ROI segmentation $\to$ Featre extraction $\to$ Feature selection $\to$ Clinical application and analysis

AP Arterial phase, CRL-R Caudate-right-lobe ratio, CLD Caudate lobe diameter, TA Texture analysis, DLS Deep learning system, ECV Hepatic extracellular volume, HU Hounsfield units, Hct 1-hematocrit, IC Iodine concentration, LSN Liver surface nodularity, LSVR Regional changes in hepatic volume, LIMV-FS Liver imaging morphology and vein diameter fibrosis score, LVD Liver vein diameter, LIMA-FS Liver imaging morphology and attenuation fibrosis score, LVCA Liver vein to cava attenuation, LIMVA-FS Liver imaging morphology, vein diameter, and attenuation fibrosis score, NIC Normalized iodine concentration, PVP Portal venous phase, RLD Right lobe diameter, ROI Circular regions of interest