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. 2023 Oct 20;34:102064. doi: 10.1016/j.omtn.2023.102064

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Vesicular trafficking and lysosomal positioning pathways are associated with the response to IFNγ in G2019S pMacs nucleofected with Lrrk2 ASO

Transcriptomic analysis from Lrrk2 ASO nucleofected G2019S pMacs treated with vehicle or IFNγ (A). Volcano plot shows proteins with fold change > 1.5 and adjusted p ≤ 0.05. (B and C) Significant DEGs were counted and compared across genotypes. (D) Heatmaps show DEGs seen only in control ASO nucleofected G2019S pMacs. (E) ShinyGO version 0.76.3 was used to identify pathways in which significant DEGs were associated with. (F) Heatmaps show DEGs seen only in G2019S pMacs nucleofected with Lrrk2 ASO.