Table 3.
Multiple linear regression analyses with the serum hs-CRP levelsa
| Variables | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| β (95% CI) | Standardized β | β (95% CI) | Standardized β | β (95% CI) | Standardized β | |
| Overall (N = 171) | ||||||
| Peak GH response to GHRP-2a, ng/mL | −0.376 (−0.511 to −0.240) | −0.413 | −0.342 (−0.537 to −0.148) | −0.377 | −0.345 (−0.533 to −0.158) | −0.380 |
| Corticotroph deficiency | — | 0.077 (−0.241 to 0.396) | 0.044 | 0.138 (−0.172 to 0.447) | 0.078 | |
| Thyroid function | ||||||
| T1 (free T4 < 1.05 ng/dL) | — | reference | reference | |||
| T2 (free T4 ≥ 1.05, <1.25 ng/dL) | — | −0.045 (−0.287 to 0.198) | −0.029 | −0.043 (−0.277 to 0.191) | −0.028 | |
| T3 (free T4 > 1.25 ng/dL) | — | 0.070 (−0.186 to 0.326) | 0.045 | 0.096 (−0.151 to 0.334) | 0.062 | |
| Hypogonadotropic hypogonadism | — | 0.058 (−0.183 to 0.299) | 0.038 | −0.024 (−0.260 to 0.213) | −0.016 | |
| Elevated liver enzymes | — | — | 0.379 (0.167 to 0.592) | 0.258 | ||
| Adjusted R2 and P value for the whole model |
R
2 = 0.277 P < .001 |
R
2 = 0.263 P < .001 |
R
2 = 0.313 P < .001 |
|||
| Patients without corticotroph deficiency, hypothyroidism, or hypogonadotropic hypogonadism (N = 111) | ||||||
| Peak GH response to GHRP-2a, ng/mL | −0.446 (−0.701 to −0.191) | −0.338 | — | — | ||
| Adjusted R2 and P value for the whole model |
R
2 = 0.183 P < .001 |
|||||
Model 1: adjusted for age, sex, obesity, hypertension, diabetes mellitus, dyslipidemia, and creatinine level. Model 2: adjusted for factors used in model 1 + corticotroph deficiency, thyroid function, and hypogonadotropic hypogonadism. Model 3: adjusted for the factors used in model 2 + elevated liver enzymes.
Abbreviations: GHRP, GH-releasing peptide; hs-CRP, high-sensitivity C-reactive protein.
a Values were log-transformed for analyses.