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. 2023 Oct 17;26(12):108225. doi: 10.1016/j.isci.2023.108225

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The proportion of CD4⁺LAG3⁺T cells in peripheral blood and its correlation with laboratory indexes

Expression of CD4, LAG3, and TGF-β3 in clinical samples.

(A) Compared with control group, the proportion of CD4⁺LAG3⁺T cells was decreased in SSc patients, and further decreased in complex with ILD. Data are represented as mean ± SD. Statistical significance was analyzed by one-way ANOVA (n = 3), ∗p < 0.05.

(B and C) Compared with control group, CD4 and LAG3 were up-regulated and TGFβ3 was down-regulated in lung tissues of SSc-ILD patients.

(D) CD4⁺LAG3⁺T cell proportion was not significantly correlated with Scl-70 and inflammatory markers CRP and ESR but was significantly negatively correlated with IL-6.

(E) Compared with control group, the TGF-β3 content in peripheral blood was decreased in SSc patients, and further decreased in complex with ILD. Data are represented as mean ± SD. Statistical significance was analyzed by one-way ANOVA (n = 5), ∗p < 0.05.