Table 2.

Subunits of SRCAP and p400/TIP60 complexes implicated in cancer biology

Subunits	Implication in cancer biology
BAF53a	Overexpressed in bladder, cervix, myeloma, colon, and ovarian cancers [21]; aberrant expression correlated with the progression of rhabdomyosarcoma, osteosarcoma, hepatocellular carcinoma, and head and neck squamous cell carcinoma [21]; BAF53a is considered to promote cancer progression via EMT epithelial–mesenchymal transition [22]
EPC1	Is mutated by chromosomal translocation in endometrial stromal sarcoma and in adult T-cell leukaemia/lymphoma SO4 cells [23–25]
GAS41	Overexpressed in glioblastoma cell lines [26, 27]
MRGBP/MRGX/MRG15	Overexpressed in colorectal cancer tissues [28]
P400	Its siRNA-mediated decrease favors the response to 5-fluorouracil of colon cancer cells [29]
Pontin & Reptin	Overexpressed in bladder, colon, liver cancers, and melanoma [21, 30, 31]
SRCAP	Mutated in large intestine, cervix, bone, endometrium, lung, urinary tract [21]; overexpressed in pancreatic cancer [21]; interacts with the CREB binding protein (CBP), an acetyltransferase encoded by a haplo-insufficient tumor suppressor gene in B-cell lymphoma [32]. It has been identified as a physiologically relevant mediator of PSA expression in prostate cancer cells [33]
Tip60	Acts as a haplo-insufficient tumor suppressor [29, 34]
YL1	Overexpressed in prostate cancer [35]