Fig. 4.

a Von Willebrand Factor (VWF) biomarker ratios and ADAMTS13 activity across different stages of portal hypertension. b Correlation between ADAMTS13 activity and VWF biomarkers in the circulation. Statistical analysis: Kruskal–Wallis with Dunn’s multiple comparisons test was used to compare continuous variables. Spearman’s correlation coefficients were calculated to assess the association between continuous variables. ADAMTS13-Act a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 activity, VWF-Ag von Willebrand factor antigen, VWF-N released N-terminal pro-peptide of von Willebrand factor, VWF-A neo-epitope of ADAMTS13 mediated degradation of von Willebrand factor, CON controls, HVPG hepatic venous pressure gradient