. 2023 Oct 11;43(8):3943–3963. doi: 10.1007/s10571-023-01417-6

Table 3.

The clinical trials among DS individuals

Study type	Participants	Type of intervention	Outcomes	References
Clinical Trials—Children	Study Group—57 Placebo Group—56	Selenium 10 μg, zinc 5 mg, vitamin A 0.9 mg, vitamin E 100 mg, and vitamin C 50 mg, folinic acid 0.1 mg	No improvement in the psychomotor and language development	Ellis (2008)
Clinical Trials—Adults	Tudy Group—26 Placebo Group—27	900 IU of α-tocopherol, 200 mg of ascorbic acid and 600 mg of alpha-lipoic acid	Improvement in cognitive functioning	Lott et al. (2011)

Study type

Participants

Type of intervention

Outcomes

References

Clinical Trials—Children

Study Group—57

Placebo Group—56

Selenium 10 μg, zinc 5 mg, vitamin A 0.9 mg, vitamin E 100 mg, and vitamin C 50 mg, folinic acid 0.1 mg

No improvement in the psychomotor and language development

Ellis (2008)

Clinical Trials—Adults

Tudy Group—26

Placebo Group—27

900 IU of α-tocopherol, 200 mg of ascorbic acid and 600 mg of alpha-lipoic acid

Improvement in cognitive functioning

Lott et al. (2011)