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. 2023 Aug 15;43(8):1927–1940. doi: 10.1007/s10875-023-01561-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — TCR CDR3 repertoire diversity and cluster formation. A The degree of the TCR repertoire diversity measured using the Gini coefficient in the CDR3 beta chain sequences. B Individual CDR3 sequence abundance distribution shown as clonal expansions. C TCR clusters. Structurally related CDR3s with the same motifs in their sequences forming network clusters (shown as nodes) in the T cell population and TCR clusters (nodes) as a proportion of the number of total TCRs being clustered for each sample