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. 2023 Nov 20;9:87. doi: 10.1038/s41522-023-00454-9

Fig. 6. In vitro competition assays demonstrate GBS inhibition by L. murinus but not E. coli.

Fig. 6

In vitro competition assays were performed between GBS and (a−c) L. murinus or (d−f) E. coli. a, d Competitive index (CI) was calculated as the CFU ratio of the treatment microbe over GBS, normalized to the initial ratio of the inoculum. The rate of bacterial growth (viable CFU) in coculture compared to monoculture controls was calculated at timepoints (b, e) 3 h and (c, f) 18 h. Symbols represent the mean of four independent experiments shown with the standard error of the mean (s.e.m.) (a−d) or independent experimental replicates (b−c, e−f) with mean and s.e.m. Data were statistically analyzed by one-sample t-test with a theoretical mean of 1.0 (a, d) and two-way ANOVA with Šídák’s multiple comparisons test for coculture deviation from growth in monoculture (b−c, e−f); *P < 0.05; **P < 0.005; ***P < 0.0005. Raw viable CFU values are reported in Fig. S7.