Table 5.
Treatment-Related Adverse Reactions in the 2 Groups
| Adverse Reactions | Pyrotinib+Radiotherapy, n (%) | Pyrotinib, n (%) | ||
|---|---|---|---|---|
| All Grades | ≥3 | All Grades | ≥3 | |
| Cognitive dysfunction | 0 | 0 | 0 | 0 |
| Diarrhea | 58 (87.9) | 16 (24.2) | 20 (76.9) | 5 (19.2) |
| Nausea | 30 (45.5) | 5 (7.6) | 12 (46.2) | 1 (3.8) |
| Anemia and Vomiting | 26 (39.4) | 0 | 11 (42.3) | 0 |
| Hand-foot syndrome | 16 (24.2) | 2 (3.0) | 6 (23.1) | 1 (3.8) |
| Fatigue | 13 (19.7) | 0 | 4 (15.4) | 0 |
| Dizziness | 10 (15.2) | 0 | 4 (15.4) | 0 |
| Rash | 5 (7.6) | 0 | 1 (3.8) | 0 |
| ALT/AST increased | 19 (28.8) | 0 | 9 (34.6) | 0 |
| Neutrophils decreased | 15 (22.7) | 3 (4.5) | 10 (38.5) | 2 (7.7) |
| Platelet decreased | 9 (13.7) | 0 | 5 (19.2) | 0 |
Abbreviations: ALT, alanine transaminase; AST, aspartate aminotransferase.