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. 2023 Nov 7;14:1303930. doi: 10.3389/fendo.2023.1303930

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Copyright © 2023 Mahmoudi-Aznaveh, Tavoosidana, Najmabadi, Azizi and Ardestani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of HepG2 derived exosomes on beta cell markers. Min6 beta cells were treated with exosomes isolated from HepG2 in the presence or absence of S961 for 24h. (A) qPCR for Pdx1, NeuroD1, Ins1, Nkx6.1, Pax6, and Pax4 mRNA expression in Min6 cells normalized to cyclophilin. Data are presented as mean ± SD (n=3-4). (B) Representative Western blot and pooled quantitative densitometry analysis of pFOXO1, FOXO1 and Actin in Min6 cells (n=2). Statistical analysis was performed using one-way ANOVA. **p < 0.01; ****p < 0.0001.