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. 2023 Nov 17;16:5367–5383. doi: 10.2147/JIR.S431628

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© 2023 Liu et al.

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Intersection and validation of ImmuneDEGs co-expressed with METTL1. Bubble plot (A) and circos plot (B) for the GO enrichment analysis of ImmuneDEGs; Bubble plot (C) and circos plot (D) for the KEGG enrichment of ImmuneDEGs; Venn diagram (E) of 8 candidate genes overlapping ImmunDEGs and METTL1-coexpressed genes; Volcano plot (F) and Heatmap (G) and for 8 candidate genes between SLE and HC; Violin plot (H) for the expression of LAMP3, CD83 and PDCDILG2 in GSE50772 dataset for validation. Mann–Whitney test. Data are means ± SEM. *P < 0.05, ***P < 0.001.

Abbreviations: ImmuneDEGs, Immune-related differentially expressed genes; METTL1, Methyltransferase like 1; SLE, Systemic lupus erythematosus; GO, Gene Ontology; BP Biological process; MF, Molecular function; CC, Cellular component; KEGG, Kyoto Encyclopedia of Genes and Genomes; M-co, DEGs METTL1-coexpressed differentially expressed genes. HC, Healthy controls; LAMP3, Lysosomal associated membrane protein 3; CD83, CD83 molecule; PDCD1LG2, Programmed cell death 1 ligand 2.