Table 4.

PanomiR prioritizes regulatory miRNAs in liver cancer using predicted interactions. Prioritized miRNAs for each identified pathway cluster, ranked by PanomiR targeting P-value (Figure 2). miRNAs are prioritized based on predicted miRNA–mRNA interaction from TargetScan V7.2. The column ‘pathways enriched’ denotes the number of pathways in the cluster with significant (FDR < 0.25) enrichment in the targets of each miRNA, derived using Fisher’s exact test

Cluster A			Cluster B			Cluster C
miRNA	Hits (#pathways enriched)	PanomiR adjusted P-value	miRNA	Hits (#pathways enriched)	PanomiR adjusted P-value	miRNA	Hits (#pathways enriched)	PanomiR adjusted P-value
hsa-miR-371a-5p	0	1.06E−38	hsa-miR-191-5p	2	2.53E−19	hsa-miR-219a-2-3p	3	1.68E−09
hsa-miR-505-3p.2	0	8.96E−34	hsa-miR-892c-3p/hsa-miR-452-5p	1	8.81E−14	hsa-miR-376c-3p	4	9.51E−09
hsa-miR-1298-5p	0	1.88E−31	hsa-miR-4424	4	4.26E−12	hsa-miR-1249-3p	0	4E−08
hsa-miR-556-5p	0	3.4E−28	hsa-miR-339-5p	3	8.51E−11	hsa-miR-3605-3p	3	1.2E−07
hsa-miR-325-3p	3	5.95E−25	hsa-miR-944	0	8.51E−11	hsa-miR-143-3p	3	2.06E−07
hsa-miR-495-3p	0	1.05E−23	hsa-miR-345-5p	1	2.03E−10	hsa-miR-514b-5p/hsa-miR-513c-5p	1	6.57E−07
hsa-miR-1278	1	1.05E−23	hsa-miR-518c-3p	0	8.89E−10	hsa-miR-187-3p	3	1.39E−06
hsa-miR-651-5p	0	1.46E−22	hsa-miR-154-5p	2	3.17E−09	hsa-miR-625-3p	1	3.06E−06
hsa-miR-323b-3p	0	6.39E−18	hsa-miR-1251-5p	1	3.47E−09	hsa-miR-1306-5p	2	5.83E−06
hsa-miR-421	0	1.16E−17	hsa-miR-599	1	3.47E−09	hsa-miR-873-5p.1	3	7.82E−06
hsa-miR-876-5p	0	1.43E−17	hsa-miR-216a-5p	1	1.21E−08	hsa-miR-155-5p	2	7.82E−06
hsa-miR-150-5p	1	1.49E−17	hsa-miR-542-3p	1	1.35E−08	hsa-miR-942-5p	3	1.40E−05
hsa-miR-487b-3p	0	4.13E−17	hsa-miR-410-3p	1	1.42E−08	hsa-miR-382-3p	2	1.40E−05
hsa-miR-542-3p	1	1.01E−16	hsa-miR-524-5p	0	1.90E−08	hsa-miR-545-5p	1	1.61E−05
hsa-miR-380-3p	0	8.57E−16	hsa-miR-7151-5p	0	1.92E−07	hsa-miR-4428	1	2.43E−05