Table 1.
Changes in insulin sensitivity and metabolic parameters with the HP and HC diets.
| HP (n = 6) | HC (n = 6) | ||||||
|---|---|---|---|---|---|---|---|
| Parameters | Baseline | 6 months | pa | Baseline | 6 months | pa | pb |
| Female/Male | 4/2 | 4/2 | |||||
| Ethnicity AA/C | 3/3 | 3/3 | |||||
| BMI (kg/m2) | 39 ± 1.8 | 36 ± 1.9 | <0.001 | 36 ± 1.7 | 33 ± 1.6 | 0.002 | 0.391 |
| WeightLoss(lbs) | 15.4 ± 2.5 | <0.001 | 19.5 ± 2.2 | <0.001 | 0.692 | ||
| Waist (cm) | 112.5 ± 3 | 105.2 ± 2 | 0.001 | 110.2 ± 3.4 | 103.5 ± 4 | 0.01 | 0.0 4 |
| HbA1c | 7.7 ± .05 | 5.6 ± .02 | 0.001 | 7.8 ± .04 | 6.7 ± .06 | 0.01 | 0.002 |
| Insulin Sensitivity | |||||||
| HOMA IR | 5.3 ± 0.29 | 2.1 ± 0.13 | 0.0001 | 5.2 ± 0.27 | 4.4 ± 0.26 | 0.03 | 0.004 |
| ISI(Matsuda I) | 1.4 ± 0.2 | 6.4 ± 0.9 | 0.0001 | 1.5 ± 0.3 | 3.0 ± 0.4 | 0.04 | 0.0001 |
| β Cell Function | 3.1 ± 0.3 | 11.1 ± 2.1 | 0.001 | 3.2 ± 0.3 | 5.26 ± 0.9 | 0.03 | 0.001 |
| % Remission of Type 2 Diabetes | 100% remission to NGT | 16.6% remission to NGT | 0.001 | ||||
ANALYSIS Mean ± SE were calculated.
a
Wilcoxon Signed Rank Test to compare baseline and 6 mo within diet group. p ≤ 0.05 was considered statistically significant.
b
Wilcoxon Rank Sum Test was used to compare variables between the two diet groups at 6 mo and.