Fig. 8.

Treatment of the Disease of Obesity. The development of anti-obesity medication is following the path of drug development of other metabolic diseases. Early anti-obesity drugs had limited weight reduction, were unsafe, poorly tolerated, and did not have proven health or mortality benefits. Current and future anti-obesity medications have the potential to be relatively safe, well tolerated, efficacious, and will (hopefully) prove to have health outcomes and improved mortality benefits [37,108,212].