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The polyketide synthesis (PKS) pathway for the synthesis of omega-3 fatty acids. The malonyl-CoA can be added to acetyl-CoA every cycle of the PKS pathway to increase two carbons on the Acyl-CoA carbon chain. However, the major difference between the PKS and FAS pathways is that 2,3-trans-enoyl-CoA can isomerize by DHi, thus generating a cis double bond during the carbon chain elongate processing without one NADPH consuming. DHi, isomerase.
