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. 2023 Nov 7;11:1299033. doi: 10.3389/fbioe.2023.1299033

FIGURE 5.

FIGURE 5

(A) Schematic diagram of the alveolar structure. Its main structure comprises upper and lower microfluidic channels. Adapted from Tan et al. (2023). Copyright 2023, Elsevier B.V. (B) A multi-organ microarray can further be used to assess the mechanism of epithelial–mesenchymal transition (EMT) in lung cancer cells invading distant tissues and organs, such as the brain, bone, and liver. Adapted from Xu et al. (2016). Copyright 2016, American Chemical Society. (C) Co-cultured lung-on-a-chip models of A549 tumour cells and HFL1 to explore the effects of HFL1 on tumour cell metastasis and drug resistance. Adapted from Yang et al. (2018). Copyright 2018, Royal Society of Chemistry. (D) The three-dimensional-culture multiorgan microfluidic (3D-CMOM) platform for the cancer treatment effects of HIF-1α inhibitors (tirapazamine, SYP-5, and IDF-11774). Adapted from Zheng et al. (2021). Copyright 2021, American Chemical Society.