Table 5.

Effect of antipsychotic medications on body weight [3]. Wide variance exists in individual weight responses to psychiatric medications. Relatively few studies exist that have directly compared individual drugs within the context of a prospective, randomized, controlled, dedicated body weight trial. Given the lack of available data and variance of data, it is challenging to objectively rank medications within a class, regarding their effects on body weight. Certain antipsychotic medications are described to be especially associated with weight gain, such as clozapine, olanzapine, and zotepine. Antipsychotic medications with variable effects on body weight include amisulpride, aripiprazole, asenapine, cariprazine, haloperidol, loxapine, lurasidone, ziprasidone, paliperidone, and perphenazine.

Antipsychotic medications	Effect on body weight
Clozapine	↑
Olanzapine	↑
Zotepine (not available in U.S.)	↑
Chlorpromazine	↑
Brexpiprazole	↑
Iloperidone	↑
Lithium	↑
Quetiapine	↑
Risperidone	↑
Thioridazine	↑