Figure S6. Deletion of the PAPSS2-PTEN locus resulted in gene expression changes in cancer patients.
(A, B) Heatmaps show the expression levels of genes in lung squamous cell carcinoma (left), skin cutaneous melanoma (middle) and uterine corpus endometrial carcinoma (right) patients identified as differentially expressed genes in HAP1 cells. The data were log10 transformed. Red: z-score > 0, blue: z-score < 0. (B) The (A) top 100 down-regulated genes ordered by FC and (B) genes with differentially acetylated H3K27 sites located within 5 kb are shown. The patient samples on the top of each heatmap are colored by groups (grey: with PAPSS2-PTEN, orange: ΔPAPSS2-PTEN). Genes with common gene expression changes across the biological replicates are highlighted by red squares.