Table 1.
Overview of data sources in this two-sample MR study.
| Exposures/outcomes | Dataset | Sample size | Number of SNPs | Population | Consortium | Sex | Year | |
|---|---|---|---|---|---|---|---|---|
| Particulate matter (PM) | PM2.5 um | ukb-b-10817 | 423,796 | 9,851,867 | European | MRC-IEU | Males and females | 2018 |
| PM2.5–10 um | ukb-b-12963 | 423,796 | 9,851,867 | European | MRC-IEU | Males and females | 2018 | |
| PM10 um | ukb-b-589 | 455,314 | 9,851,867 | European | MRC-IEU | Males and females | 2018 | |
| Nitrogen dioxide | ukb-b-2618 | 456,380 | 9,851,867 | European | MRC-IEU | Males and females | 2018 | |
| Nitrogen oxides | ukb-b-12417 | 456,380 | 9,851,867 | European | MRC-IEU | Males and females | 2018 | |
| Frailty index | ebi-a-GCST90020053 | 175,226 | 7,589,717 | European | NA | NA | 2021 | |
PM, Particulate matter; MR, Mendelian randomization; SNPs, Single nucleotide polymorphisms; MRC-IEU, Medical Research Council Integrative Epidemiology Unit; NA, Not available.