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. 2023 Nov 20;6:1179. doi: 10.1038/s42003-023-05548-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Heatmap of scaled gene counts of significantly differentially expressed genes (p < 0.05) between IPD and control NESCs. b Log2FC of the top significantly expressed genes (FDR < 0.05) displaying gene expression difference in IPD NESCs compared to control cells. c The most dysregulated metabolic pathways, selected by the average of Log2FC < −1 or >1 of genes annotated in each pathway. The color represents the Log2FC. d Principal component scores plot of non-polar metabolites detected by untargeted GC-MS analysis. e Principal component scores plot of polar metabolites detected by untargeted GC-MS analysis.