Table 1.
Summary of the matched replicated metabolites.
| VMH ID | Common name | # Increased | # Decreased | Inconsistent | Increased samples | Decreased samples |
|---|---|---|---|---|---|---|
| nrpphr | Norepinephrine | 0 | 2 | 0 | – | Plasma38,39 |
| dopa | Dopamine | 2 | 2 | 1 | Plasma69; CSF70 | Plasma38; Serum42 |
| ins | Inosine | 0 | 2 | 0 | – | Plasma42; CSF43 |
| gly | Glycine | 6 | 0 | 0 | Plasma38,48; Serum44; Urine45,46; Saliva47 | – |
| citr_L | Citrulline | 0 | 3 | 0 | – | Serum40–42 |
| gln_L | Glutamine | 8 | 1 | 1 | Plasma48,71,72; Serum44,73; Putamen74; CSF70; Urine75 | CSF76 |
| asp_L | Aspartic acid | 3 | 1 | 1 | Plasma38; Urine45; Serum77 | Serum44 |
| ile_L | Isoleucine | 6 | 1 | 1 | Serum73; CSF72; Fecal78; Urine45,75; Saliva47 | Fecal79 |
| met_L | Methionine | 3 | 2 | 1 | Plasma49,76; CSF70 | Plasma49,80 |
| ser_L | Serine | 2 | 2 | 1 | Plasma49; CSF76 | Serum41,44 |
| tyr_L | Tyrosine | 10 | 3 | 1 | Plasma39,48,81; Serum44,74,77,82; Urine45,75; Saliva47 | Fecal79,83; Plasma84 |
| val_L | Valine | 2 | 1 | 1 | Serum73; Saliva47 | Fecal79 |
| 4abut | GABA | 4 | 0 | 0 | Plasma38; Urine45,46; Saliva47 | – |
| cit | Citric acid | 4 | 2 | 1 | Plasma85; Serum73,86; CSF70 | Plasma87; Serum44 |
| crn | Carnitine | 1 | 2 | 1 | Plasma88 | Plasma89; CSF70 |
Metabolites identified in metabolic modeling to be changed in IPD cells and also associated with PD diagnosis in more than one clinical study. VMH ID: metabolite name in Recon 3D.