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. 2023 Nov 20;24:63. doi: 10.1186/s40360-023-00698-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — BDMC administration inhibits inflammatory responses in ALI mice. Mice were intragastrically administered with BDMC (100 mg/kg/day) for 3 days, and then intratracheally injected with a single dose of LPS (5 mg/kg). Mice were sacrificed 12 h post-LPS injection with the lungs collected for further examination. (A-C) The levels of inflammatory cytokines were assessed in murine lungs (n = 6). (D-E) The levels of inflammatory cytokines were assessed in BALF (n = 6). (F-H) The infiltrations of total cells, macrophages and neutrophils in BALF (n = 6). (I) The MPO activity in lung tissues (n = 6). (J-L) The western blot images and quantitative data of p65 phosphorylation and nuclear translocation (n = 6). Values represent the mean ± SD. *P<0.05 versus Saline + Vehicle; ^#P<0.05 versus LPS + Vehicle