Table 2.
Determination for risk factors for DFS or OS by univariate tests
| DFS | OS | |||
|---|---|---|---|---|
| P | HR (95% CI) | P | HR (95% CI) | |
| Age (y) | ||||
| < 60 | 1 | 1 | ||
| ≥ 60 | 0.033* | 1.78 (1.05–3.01) | 0.072 | 2.09 (0.94–4.64) |
| Sex | ||||
| Male | 1 | 1 | ||
| Female | 0.001* | 0.37 (0.21–0.66) | 0.002* | 0.19 (0.06–0.55) |
| Type of resection | ||||
| Lobectomy | 1 | 1 | ||
| Segmentectomy | 0.105 | 1.86 (0.88–3.95) | 0.100 | 3.37 (0.79–14.32) |
| Pathology | ||||
| ADC | 1 | 1 | ||
| SCC | 0.196 | 1.84 (0.73–4.67) | 0.023* | 3.52 (1.19–10.44) |
| Others | 0.006* | 4.28 (1.53–12.02) | 0.091 | 3.54 (0.82–15.34) |
| Smoking status | ||||
| Never | 1 | 1 | ||
| Current + former | < 0.001* | 3.19 (1.88–5.40) | < 0.001* | 4.45 (1.96–10.08) |
| Alcohol status | ||||
| Never | 1 | 1 | ||
| Current + former | 0.126 | 1.51 (0.89–2.57) | 0.024* | 2.49 (1.13–5.49) |
| Comorbidity | ||||
| With | 1 | 1 | ||
| Without | 0.880 | 0.95 (0.52–1.75) | 0.295 | 0.57 (0.19–1.65) |
| T stages | ||||
| T1 + T2 | 1 | 1 | ||
| T3 + T4 | 0.002* | 5.16 (1.86–14.31) | 0.058 | 4.07 (0.95–17.37) |
| N stages | ||||
| N0 | 1 | 1 | ||
| N1 + N2 | < 0.001* | 9.70 (5.63–16.71) | < 0.001* | 14.47 (6.26–33.46) |
| TNM stages | ||||
| I | 1 | 1 | ||
| II | < 0.001* | 7.06 (3.66–13.64) | < 0.001* | 9.34 (3.50–24.92) |
| III | < 0.001* | 20.36 (12.74–50.49) | < 0.001* | 24.23 (9.23–63.60) |
| NSAIDs UI | ||||
| Low | 1 | 1 | ||
| High | 0.001* | 0.38 (0.21–0.68) | 0.010* | 0.27 (0.10–0.73) |
UI use intensity, ADC adenocarcinoma, SCC squamous carcinoma, DFS disease-free survival, OS overall survival
*With significant difference