Table 1.

The 12-step 6-h rapid drug desensitization protocol defined by Lee et al in 2004.

Standard desensitization protocol using a total dose of 500 mg as an example
Total dose	500 mg	Solution concentration	Total dose in each solution (mg)
Solution A	250 mL	0.02 ng/mL	5.0*
Solution B	250 mL	0.20 ng/mL	50.0*
Solution C	250 mL	2.00 ng/mL	500.0*
Step	Solution	Rate (mL/h)	Time (min)	Administered dose (mg)	Cumulative dose (mg)
1	A	2	15	0.010	0.010
2	A	5	15	0.025	0.035
3	A	10	15	0.050	0.085
4	A	20	15	0.100	0.185
5	B	5	15	0.250	0.435
6	B	10	15	0.500	0.935
7	B	20	15	1.000	1.935
8	B	40	15	2.000	3.935
9	C	10	15	5.000	8.935
10	C	20	15	10.000	18.935
11	C	40	15	20.000	38.935
12	C	75	15	461.065	500.000
			Total time = 5.82 h		Total dose infused = 500 mg*