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. 2023 Nov 21;21:126. doi: 10.1186/s12955-023-02206-x

Table 7.

Mean change in PROMIS SD-SF-8b total score: PGI-S SD and PGI-C SD categories

Categories N Mean change Median change 95% CI
PGI-S SD
Baseline to week 4
  All categories
   Improved 3 points 6 – 19.00 – 20.50 – 29.09, – 8.91
   Improved 2 points 102 – 12.25 – 12.00 – 13.66, – 10.85
   Improved 1 point 341 – 6.07 – 6.00 – 6.65, – 5.49
   No change 377 – 1.02 – 1.00 – 1.58, – 0.46
   Worsened 1 point 97 3.70 4.00 2.53, 4.88
   Worsened 2 points 9 10.56 9.00 6.58, 14.53
   Worsened 3 points 0
  Collapsed categories
   Improved ≥ 2 points (collapsed) 108 – 12.63 – 13.00 – 14.04, – 11.22
   Worsened ≥ 2 points (collapsed) 9 10.56 9.00 6.58, 14.53
 Baseline to week 12
  All categories
   Improved 3 points 12 – 18.33 – 22.00 – 23.43, – 13.23
   Improved 2 points 120 – 11.28 – 11.50 – 12.51, – 10.04
   Improved 1 point 313 – 6.30 – 6.00 – 6.92, – 5.68
   No change 311 – 1.17 – 1.00 – 1.78, – 0.57
   Worsened 1 point 98 3.35 3.00 2.16, 4.53
   Worsened 2 points 10 7.30 7.00 2.73, 11.87
   Worsened 3 points 0
  Collapsed categories
   Improved ≥ 2 points (collapsed) 132 – 11.92 – 12.00 – 13.16, – 10.67
   Worsened ≥ 2 points (collapsed) 10 7.30 7.00 2.73, 11.87
PGI-C SD
 Baseline to week 4
  All categories
   Much better 160 – 10.98 – 10.00 – 12.12, – 9.84
   Moderately better 152 – 5.93 – 6.00 – 6.86, – 4.99
   A little better 265 – 3.80 – 4.00 – 4.51, – 3.09
   No change 291 0.33 0.00 – 0.32, 0.98
   A little worse 39 2.82 4.00 0.52, 5.12
   Moderately worse 16 3.38 4.00 0.86, 5.89
   Much worse 8 4.63 5.00 0.09, 9.16
  Collapsed categories
   Much or moderately better 312 – 8.52 – 8.00 – 9.31, – 7.73
   Moderately worse or much worse 24 3.79 4.00 1.73, 5.85
   Improvement 577 – 6.35 – 6.00 – 6.92, – 5.78
   No change 291 0.33 0.00 – 0.32, 0.98
   Worsening 63 3.19 4.00 1.60, 4.78
 Baseline to week 12
  All categories
   Much better 189 – 9.69 – 10.00 – 10.71, – 8.67
   Moderately better 170 – 5.87 – 6.00 – 6.77, – 4.97
   A little better 231 – 3.59 – 3.00 – 4.45, – 2.74
   No change 198 – 0.56 0.00 – 1.38, 0.26
   A little worse 37 3.00 2.00 1.20, 4.80
   Moderately worse 29 4.03 4.00 1.72, 6.35
   Much worse 8 6.63 4.50 1.90, 11.35
  Collapsed categories
   Much or moderately better 359 – 7.88 – 8.00 – 8.59, – 7.17
   Moderately worse or much worse 37 4.59 4.00 2.59, 6.60
   Improvement 590 – 6.20 – 6.00 – 6.77, – 5.63
   No change 198 – 0.56 0.00 – 1.38, 0.26
   Worsening 74 3.80 3.00 2.47, 5.13

Bolded categories were used for the triangulation of meaningful change thresholds

CI Confidence interval, PGI-C SD Patient Global Impression of Change Sleep Disturbance, PGI-S SD Patient Global Impression of Severity Sleep Disturbance, PROMIS SD-SF-8b Patient-Reported Outcomes Measurement Information System Sleep Disturbance – Short Form 8b