Table 2.
1H MRS Measures in Healthy Controls, Primary Insomnia, and Major Depression.
| REGION OF INTEREST | 1H MRS Measuresa | Healthy Controls (Mean, SD) | Primary Insomnia (Mean, SD) | Major Depressive Disorder (Mean, SD) | F | P-value (two tailed) | df | Tukey Kramer Post-Hoc Contrasts |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Anterior Cingulate Cortex | GABA + /Cr | 0.19 (0.03) | 0.19 (0.06) | 0.18 (0.04) | 0.75 | 0.474 | 80 | |
| Glu/Cr | 1.00 (0.20) | 0.93 (0.19) | 0.86 (0.18) | 4.97 | 0.009 | 95 | MDD<HC <.01 | |
| Creatine | 161.48 (42.25) | 170.93 (42.34) | 165.97 (37.72) | 0.34 | 0.71 | 99 | ||
| Parieto-Occipital Cortex | GABA + /Cr | 0.21 (0.03) | 0.20 (0.05) | 0.22 (0.04) | 1.21 | 0.302 | 98 | |
| Gtu/Cr | 0.83 (0.10) | 0.79 (0.13) | 0.84 (0.08) | 2.60 | 0.080 | 95 | ||
| Creatine | 219.2 (40.78) | 214.83 (45.27) | 217.44 (34.02) | 0.08 | 0.93 | 98 | ||
a
Values reportd only include subjects with Cramér-Rao < 20%.