Figure 2. Associations Between sNfL Levels Recent Attack Severity and Clinical and Subclinical Disease at Sampling in Treatment-Naive Pediatric Patients With MS.

In patients with a recent relapse (≤90 days) before serum sampling, higher sNfL levels were associated with (A) polyfocal symptoms during the attack and (B) incomplete recovery 3 months after the attack. Both clinical (C, D) and subclinical disease (E, F) in the untreated patients showed associations with sNfL. Boxplots depict median and interquartile range with whiskers extending to minimum and maximum values. MS = multiple sclerosis; sNfL = serum neurofilament light chain.