Table 2.

Multiple Regression Models Assessing Predictors of Log-Transformed sNfL in Treatment-Naive Pediatric Patients With Multiple Sclerosis

	Beta (95% CI)	p Value	sr	R 2
Model 1: Clinical and MRI disease activity (N = 121)				0.34
Age at sampling	−0.347 (−0.507 to −0.186)	<0.001	−0.325
Sex	0.032 (−0.123 to 0.187)	0.682	0.031
Disease duration at sampling (log-transformed)	−0.178 (−0.380 to 0.024)	0.084	−0.132
Relapse ≤90 d before sampling	0.026 (−0.174 to 0.226)	0.796	0.020
>1 relapse in 12 mo preceding sampling	0.141 (−0.048 to 0.331)	0.143	0.112
Gd+ lesions present ≤30 d before sampling	0.238 (0.073 to 0.403)	0.005	0.217
No. of T2 lesions ≤6 mo presampling (log-transformed)	0.337 (0.171 to 0.502)	<0.001	0.306
Model 2: Disease activity and attack severity (N = 85)				0.43
Age at sampling	−0.239 (−0.406 to −0.070)	0.006	−0.233
>1 relapse in 12 mo preceding sampling	0.120 (0.051 to 0.291)	0.166	0.116
Incomplete recovery 3 mo after a relapse ≤90 d before sampling	0.308 (0.138 to 0.479)	<0.001	0.298
Gd+ lesions present ≤30 d before sampling	0.209 (0.028 to 0.390)	0.024	0.190
No. of T2 lesions ≤6 mo presampling (log-transformed)	0.324 (0.149 to 0.500)	<0.001	0.305

Abbreviations: Gd+ = gadolinium-enhancing; sNfL = serum neurofilament light; sr = semipartial correlation coefficient.