Table 3.

Results of Generalized Linear Model of 8-Year Subiculum Volumes in All Participants Examining the Association With Total Neonatal Midazolam Dose

Characteristics	B	95% CI	p Value
8 y ages (mo)	−0.02	−0.87 to 0.84	0.97
Gestational age at birth (weeks)	1.72	−7.505 to 10.95	0.72
Sex (male)	29.18	0.941 to 57.41	0.04a
Culture-positive infection	−38.52	−73.01 to −4.03	0.03a
Surgery ≥1	−28.03	70.134 to −14.06	0.19
Fentanyl doseb	−1.81	−11.352 to 7.73	0.71
Morphine doseb	−0.05	−0.73 to 0.63	0.89
Midazolam doseb	−2.93	−5.105 to −0.75	0.008a
Hydrocortisone doseb	−0.17	−1.353 to 1.02	0.79
Days of mechanical ventilation	−0.23	−1.228 to 0.76	0.65
Total skin-breaking proceduresc	0.38	0.029 to 0.72	0.03a
TCV	0.0002	0.0001 to 0.0003	<0.001a

Abbreviations: GA = gestational age; TCV = total cerebral volume.

^aStatistically significant, p < 0.05.

^bTotal dose in milligrams from birth until hospital discharge.

^cTotal invasive procedures from birth until hospital discharge.