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. 2023 Sep 22;101(11):1449–1464. doi: 10.1007/s00109-023-02369-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — LOXL2 is highly expressed in patients with gemcitabine-resistant pancreatic cancer and gemcitabine-resistant pancreatic cancer cells. A Immunohistochemical staining of LOXL2 in pancreatic cancer tissues. B Bar graphs for LOXL2 levels in tissues between the resistant and sensitive groups. C Dot plot of LOXL2 gene expression level in purified mRNA from pancreatic cancer patient tissue. D Schematic showing the establishment of a gemcitabine-resistant cell line. E WST-1 assay of parental Miapaca2 (Mia Con) and gemcitabine-resistant (Mia GR) cells exposed to gemcitabine at different concentrations for 72 h. F and G Relative mRNA levels of the indicated genes in Miapaca2 and Mia GR cells. H The protein expression of LOXL2, RRM1, hENT1, and DCK was compared between Mia Con and Mia GR cells using western blot analysis. All western blot experiments were performed at least three times