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. 2023 Nov 8;14:1297352. doi: 10.3389/fimmu.2023.1297352

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Copyright © 2023 Dudler, Yaseen and Cummings

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacokinetics and pharmacodynamics of narsoplimab in cynomolgus monkeys after a single IV infusion of narsoplimab. (A) Dose-dependent exposure after a single IV dose. (B) Dose-related pharmacodynamic effect. (C) Concentration-dependent pharmacodynamic effect. * % inhibition of the lectin pathway was determined ex vivo by mannan-induced C4 activation with an ELISA assay. EC₅₀, half-maximal effective concentration; IV, intravenous.