Table 3.
Affinity of narsoplimab for MASP-1, MASP-2, MASP-3, C1r, and C1s.
| Antigen | Narsoplimab K D (nM) |
|---|---|
| MASP-1 | > 500 a |
| Zymogen MASP-2 | 0.062 ± 0.023 b |
| Active MASP-2 | 0.089 ± 0.012 b |
| MASP-3 | > 500 a |
| C1r | > 500 a |
| C1s | ~ 500 c |
C, complement component; KD , dissociation equilibrium constant; MASP, mannan-binding lectin-associated serine protease.
a
Narsoplimab at 500 nM yielded less than half of the MASP-2 binding response.
b
Mean ± SD; n = 12.
c
Narsoplimab at 500 nM yielded approximately half of the MASP-2 binding response.