TABLE 3.
Proposed expanded criteria for liver transplantation and associated outcomes
| Examples of expanded criteriaa | Post-transplant survival | |
|---|---|---|
| UCSF criteria[207] | One tumor ≤ 6.5 cm or 2–3 tumors, each ≤ 4.5 cm, with total tumor volume ≤ 8 cm | 81% 5-year survival |
| Total tumor volume < 115 cm[208] | Sum of volume for each tumor ≤ 115 cm3 | 75% 4-year survival |
| Up-to-seven criteria[209] | Diameter or largest tumor (cm) + number of tumors ≤ 7 | 71% 5-year survival |
| Extended Toronto criteria[210] | Biopsy demonstrating well-to-moderate differentiation for patients beyond Milan criteria and ECOG performance status 0–1 | 68% 5-year survival |
| Kyoto criteria[211] | Number or tumors ≤ 10, maximum diameter of each tumor ≤ 5 cm, and serum DCP ≤ 400 mAU/ml | 65% 5-year survival |
Abbreviations: DCP, des-gamma carboxyprothrombin; ECOG, Eastern Cooperative Oncology Group; UCSF, University of California, San Francisco.
a
All criteria include absence of vascular invasion and metastatic spread.