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. 2023 Nov 22;14:7600. doi: 10.1038/s41467-023-43373-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Distribution of tumor ploidy. Tumors with a ploidy higher than 2.5 (dashed line) are considered whole genome doubling (WGD). Each dot represents a sample (circle, PT; triangle, PDX). The boxes and middle lines within represent the interquartile range (IQR) and median. The top and bottom whiskers represent values within 1.5×IQR of the upper and lower quantiles respectively. b Ploidy correlation between PT and PDX. Each dot represents a pair. The correlation coefficient and p-value were calculated with Spearman’s rank correlation test. Black solid line is the linear regression line, and the error band corresponds to 95% confidence interval. The two outliers (1959 and 1979) were excluded from the regression and correlation analyses. c Pairwise correlation in copy number profiles between PTs and PDXs based on 1 Mb windows. The top color bar indicating tumor type is interpreted the same as in (b). Samples labeled in red are from group 2. d Overlaps of focal SCNAs. For each patient, the left bar presents the PT and the right bar represents the PDX. Counts of shared events are different in PT and PDX because of variations in segmentation boundaries. Only the nine PT/PDX pairs where focal SCNAs were found are shown. Source data are provided as a Source Data file.