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. 2023 Nov 21;14:7578. doi: 10.1038/s41467-023-43039-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — EC-Atm^-/- and control mice were subjected to (i) 7 weeks of room air (Normo), or (ii) 3 weeks of hypoxia (10% O₂, Hx) only, or (iii) 3 weeks of hypoxia (10% O₂), followed by 4 weeks of reoxygenation in normoxia (Reoxy). Right ventricular (RV) systolic pressure (RVSP), RV hypertrophy (weight of RV/left ventricle and septum, RV/LV + S), number of vessels per 100 alveoli at alveolar wall and duct level, and the percentage of fully or partially muscularized pulmonary arteries in (a) male mice (Control: Normo n = 6, Hx n = 6, Reoxy n = 8; EC-Atm^-/-: Normo n = 5, Hx n = 4, Reoxy n = 7) and (b) female mice (Control: Normo n = 5, Hx n = 6, Reoxy n = 7; EC-Atm^-/-: Normo n = 6, Hx n = 5, Reoxy n = 8). Each data point represents a mouse. Bars represent mean ± S.E.M. P values determined by 2-way ANOVA with Holm-Sidak posthoc test. ns, not significant. c Representative images of αSMA staining of lung section in EC-Atm^-/- mice. Scale bars, 20 μm. Inserts in the lower left corners show a magnified image of vessels delineated by the black lines (Scale bars, 20 μm). Source data are provided as a Source Data file.