Table 1.
Study characteristics.
| Study | Year | Sample size (n) | Age (year) | Duration of infertility (year) | BMI (kg/m2) | GH dose | Stimulation protocol | Outcomes | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| T/C | T | C | T | C | T | C | |||||
| He (20) | 2023 | 32/32 | 33 (32, 37) | 34 (31, 38) | 4.5(2.0,7.3) | 2(1.0, 5.3) | 20.7(19.9, 21.8) | 20.9(19.5, 23.3) | 3 IU/d | Minimal stimulation protocol | ②⑦⑩ |
| Shi (13) | 2022 | 48/48 | 36.15 ± 3.02 | 36.73 ± 2.85 | 4.08 ± 1.35 | 4.11 ± 1.37 | 23.30 ± 2.11 | 23.31 ± 2.01 | 4 IU/d | GnRH antagonist protocol | ①②③⑥⑦⑧⑨⑩⑪⑫⑬ |
| Wei (21) | 2022 | 24/24 | 40.36 ± 2.24 | 40.23 ± 2.18 | NA | NA | NA | NA | 4 IU/d | GnRH antagonist protocol | ②③⑥⑦ |
| Xin (23) | 2022 | 37/37 | 27.75 ± 2.02 | 27.93 ± 2.14 | 4.30 ± 0.49 | 4.27 ± 0.45 | 22.06 ± 2.16 | 22.13 ± 2.01 | 4 IU/d | GnRH antagonist protocol | ①②③⑨⑩⑪⑫⑬ |
| Kang (15) | 2020 | 36/38 | 39.63 ± 4.85 | 40.15 ± 4.69 | 5.17 ± 1.72 | 5.21 ± 1.70 | NA | NA | 5 IU/d | GnRH antagonist protocol | ①②⑤⑧⑨⑩⑪⑫⑬ |
| Tang (25) | 2019 | 40/42 | 31.0 ± 3.0 | 30.0 ± 3.0 | 4.0 ± 2.5 | 3.6 ± 2.3 | 21.7 ± 2.6 | 22.8 ± 3.6 | 5 IU/d | Short GnRH agonist protocol | ①②⑩⑫⑬ |
| Wang (22) | 2018 | 45/44 | 38.21 ± 3.95 | 38.19 ± 3.93 | NA | NA | NA | NA | 4.51 IU/d | GnRH antagonist protocol | ①②③⑥⑦⑩⑫⑬ |
| Zhang (16) | 2018 | 60/60 | 37.42 ± 1.19 | 37.91 ± 1.75 | 5.64 ± 2.80 | 5.92 ± 2.16 | NA | NA | NA | Short GnRH agonist protocol | ①②③⑤⑥⑦⑨ |
| Zhao (14) | 2017 | 50/50 | 38.25 ± 4.52 | 37.38 ± 4.75 | NA | NA | NA | NA | 4.5 IU/d | GnRH antagonist protocol | ②③⑩⑪⑫⑬ |
| Lin (24) | 2017 | 55/50 | 36.62 ± 3.17 | 37.42 ± 3.23 | NA | NA | 23.31 ± 3.73 | 23.09 ± 3.79 | 4.5 IU/d | Long GnRH agonist protocol | ①②③⑤⑧⑨⑩⑪⑫⑬ |
T, trial group; C, control group; BMI, body mass index; GH, growth hormone; NA, not available; GnRH, gonadotropin-releasing hormone; ① Clinical pregnancy rate; ② Number of oocytes retrieved; ③ Optimal embryos rate; ④ Number of optimal embryos; ⑤ Cycle cancellation rate; ⑥ Cleavage rate; ⑦ Fertilization rate; ⑧ Embryo implantation rate; ⑨ Miscarriage rate; ⑩ E2 levels on the day of hCG; ⑪ Endometrial thickness on the day of hCG; ⑫ Total days of Gn used; ⑬ Total dose of Gn used.