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. 2023 Aug 14;19(4):729–736. doi: 10.4103/1673-5374.382227

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Copyright: © Neural Regeneration Research

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Autophagic gene and pathway abnormalities in microglia and astrocytes affecting pathophysiology of AD and PD.

Diagram illustrating various autophagy genes and pathways in microglia and astrocyte aggravating the pathology of AD and PD brain. Text of the same color indicating the autophagic gene or pathway with causative symptoms. Created with Microsoft PowerPoint. AD: Alzheimer’s disease; Aβ: amyloid-beta; GBA: glucosylceramidase beta; IDE: insulin-degrading enzyme; LRRK2: leucine-rich repeat kinase 2; NFT: neurofibrillary tangle; PD: Parkinson’s disease; SNCA: alpha-synuclein; TFEB: transcription factor EB.